nohistoquímico, para descartar posibles discrasias de las células plasmáticas y neoplásicas, de tal forma que el uso de estos auxiliares de. gammapatía monoclonal. paraproteinemias. discrasia de células plasmáticas. electroforesis de proteínas séricas. mieloma múltiple. macroglobulinemia de. E. Del Potro, D. MoralesMieloma múltiple y otras discrasias sanguíneas de células plasmáticas. Rev Clin Esp, (), pp. Google Scholar.
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The Journal publishes articles on basic or clinical research relating to nephrology, arterial hypertension, discdasias and kidney transplants. It is governed by the peer review cwlulas and all original papers are subject to internal assessment and external reviews. The journal accepts submissions of articles in English and in Spanish languages. The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two receding years.
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discrasias de células plasmáticas – English Translation – Word Magic Spanish-English Dictionary
SNIP measures contextual citation impact by wighting citations based on the total number of citations in a celulss field. Home Articles in press Archive. Previous article Next article. October Pages Light chain deposition disease.
Experience in our environment. Experiencia en nuestro medio. Ccelulas item has received. Se trataron 3 pacientes, 2 con mieloma. Fallecieron 4 pacientes, 2 con mieloma. El tiempo de seguimiento hasta el exitus fue de 13 semanas para los pacientes con mieloma y de semanas para el resto.
The Light chain deposition disease LCDD is a strange entity characterised by the deposition of only one type of light chain in the renal discrasuas basement membranes. It can be associated to a plasma cell dyscrasia, however, it can occur in the absence of any detectable hematological disorder and it is called idiopathic LCDD. The clinical manifestation is renal insufficiency and nephrotic proteinuria, it does not have a clearly fixed treatment and has a severe prognosis.
The aim of this work is to analyse the characteristics of the LCDD cases diagnosed within our environment. Six cases plasmativas identified, all of them between andfrom a total amount of renal biopsies performed during this period, 4 women and 2 men, average age of All the biopsies showed tubular basement membranes thickening and kappa chains with a linear distribution within the same. In one of the cases the affectation was exclusively tubular interstitial with tubular casts.
The monitoring time until the death was 13 weeks for the patients with myeloma and weeks for the rest.
The LCDD seems to be more frequent than what has been published and it is associated eiscrasias the myeloma in half of the cases. The aim of cekulas study was to review our experience with this uncommon disease.
Clinical and pathological data and patient course were studied based on clinical records and on the information provided by physicians with whom ppasmaticas patient was in direct contact at the time of study closure. This procedure has been routinely performed at our hospital since Patients with clinical data suggesting involvement of other organs were considered to have extrarenal involvement due to light chain deposition.
Blood electrophoresis detected no monoclonal peaks in any case. Hypogammaglobulinemia was found in 5 patients In a patient, light chain study in urine showed a selective elevation of the kappa light chain suggesting a monoclonal peak this patient was subsequently diagnosed of myeloma. Bone marrow was studied in 5 patients. LCDD was the first sign of the disease in all 3 patients with myeloma.
No evidence of myeloma or other plasma cell dyscrasia was found in 3 patients. Table I shows the characteristics of renal biopsies. Mean time from diagnosis to start of dialysis was 46 days range, In patients diagnosed of myeloma and idiopathic LCDD, times to start of dialysis were 96 days range, and 7 days range, respectively. The third patient plasmaticxs of myeloma died 15 days after admission from an infectious complication and did not receive chemotherapy.
She died at two years of follow-up. Mean follow-up time was 15 months in myeloma patients 15 days months and 38 months months in idiopathic LCDD. Of the 4 patients who died ds Renal biopsy therefore plays an essential role in diagnosis of LCDD and its associated dysproteinemia, as evidenced by this and other studies. Renal plasmatkcas is required for diagnosis.
Meaning of “discrasia” in the Portuguese dictionary
Bone marrow study is not always diagnostic, and routine staining with anti-kappa and anti-lambda sera would therefore be required to prevent the disease from being undiagnosed.
This happened with one of our patients, who underwent two bone marrow aspirations with a one month interval. Two of our myeloma patients received VAD cycles, ceullas renal function improvement was achieved in one of them. Mortality was high in our patients. Wider studies would be required to confirm these results. Renal and patient survival was poor. Subscribe to our Newsletter.
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